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In β3-AR knockout mice, however, no effect was observed with AOD9604 — confirming the dependency of its chronic lipolytic action on β3-AR expression, while also suggesting an additional acute mechanism that may operate through a separate pathway

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These investigations consistently indicate a lack of evidence supporting a causal relationship between elevated serum urate levels and the risk of developing type 2 diabetes mellitus, coronary heart disease, ischemic stroke, and heart failure