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Normally, the kelch-like erythroid-cell-derived protein with CNC homology (ECH)-Associated protein-1-Nrf2-(Keap-1-Nrf2-ARE) signaling pathway elicits an adaptive response for cell survival under OS, but they did not appear to operate effectively in periodontitis patients.[99] Therapeutic considerations of glutathione Glutathione supplementation may help to prevent or treat many conditions associated with impaired immune function due to elevated OS or aging [Table 6].[117] It has been postulated that raising glutathione levels in cells have reduced cancer growth by suppressing the activity of certain chemically-reactive oxygen molecules in the test tubes
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doi: 10.1038/s41420–022-00931–8 200 ZhangBChenXRuFGanYLiBXiaWet al
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