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Methionine is first converted to S-adenosylmethionine (SAMe), which donates its methyl group and is subsequently converted through several steps to homocysteine, then to cystathionine, and finally to cysteine via the enzyme cystathionine β-lyase.⁴ This pathway has limited capacity, and supplemental L-cysteine bypasses this bottleneck entirely, providing a direct substrate for glutathione synthesis without requiring hepatic conversion from methionine