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The combination works through complementary mechanisms: GLP-1 agonist → appetite suppression → caloric deficit → forces the body to use stored energy AOD-9604 → directly stimulates fat cells to release that stored energy + inhibits new fat storage In practice, users report that AOD-9604 helps address stubborn fat deposits — particularly visceral and lower abdominal fat — that persist even on effective GLP-1 therapy

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Its role in directly regulating the SAM:SAH ratio in cells implicates NNMT in playing a significant role in controlling the gene expression within ovarian cancer cells and cancer-associated fibroblasts (CAFs) (Figure 3C)