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The preservation of proteostasis plays a crucial role in cell survival and becomes even more important for nondividing cells such as neurons, whose proteostasis machineries are reduced with aging, causing an accumulation of damaged organelles and misfolded proteins (327–329)
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Other causes of the patient’s symptoms, such as hypothyroidism and deficiency of vitamin D, B12 or folic acid, were checked, and treated if found
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