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Differentiation of Treg cells Naturally occurring Tregs (nTregs) are derived from the thymus and differentiate upon TCR recognition of self-antigen–MHC complexes, subsequently expressing high levels of Foxp3 to maintain self-tolerance [56]
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However, visceral adipose tissue from healthy obese (insulin sensitive obese) subjects exhibits less pro-inflammatory profile compared to the insulin resistant obese subjects, which manifests itself by decreased macrophage infiltration and decreased expression of interleukin-6 and interleukin-1β [52]
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