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The phenyl ring of F23 Cagri forms extensive van der Waals contact with L16 Cagri , Y149 1.40 , Y146 1.37 (superscript numbers for receptor residues refer to the class B1 GPCR numbering scheme 17 ), anchoring the peptide segment with the CTR transmembrane (TM) bundle level with the micelle interface

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This rat model expresses mutant human “Swedish” amyloid precursor protein (APPsw) and a Δ exon 9 presenilin-1 (PS1ΔE9) at levels 2.6 and 6.2 times higher than the endogenous rat proteins, respectively (Cohen et al., 2013)