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PDF) Risk of Vitamin B12 Deficiency Associated with Proton Pump Inhibitors, Metformin, and H2 Blockers in Geriatric Patients: A Polypharmacy Perspective

Certainly, the synthesis of GSH does not take place in the nucleus because, like mitochondria, it lacks the enzymes required for GSH biosynthesis [26]

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This finding aligns with the mitochondrial dysfunction discussed in Chapter 2: mitochondrial damage in peripheral skeletal muscle is reflected as regional glucose hypometabolism in the central nervous system