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Phase IIb of the study reported predicted improvements in PD total and motor scores, although they were not significantly different from the placebo group

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The linker-payload according to claim 10, wherein E has the formula of: P , R1 is -C(O)-, -O-, -S-, -NH-, -C(O)O-, alkyl-C(O)-NH-, alkyl-NH-C(O)-, alkyl-CO2-, alkyl-S-, or 2 is H, SO 3 H, PO 3 H 2 , a sugar derivative, C 1 -C 10 (hetero) alkyl group, C 3 -C 10 (hetero) cycloalkyl group, C2-C10 alkyl-NH2, C1-C10 alkyl-COOH, C2-C10 alkyl-NH(C1-C3 alkyl), C2-C10 alkyl-N (C1- C3 alkyl)2, or sarcosines